Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites
Identifieur interne : 002905 ( Main/Exploration ); précédent : 002904; suivant : 002906Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites
Auteurs : Clare M. Smith [Australie] ; Ante Jerkovic [Australie] ; Hervé Puy [France] ; Ingrid Winship [Australie] ; Jean-Charles Deybach [France] ; Laurent Gouya [France] ; Giel Van Dooren [Australie] ; Christopher Dean Goodman [Australie] ; Angelika Sturm [Australie] ; Hana Manceau [France] ; Geoffrey Ian Mcfadden [Australie] ; Peter David [France] ; Odile Mercereau-Puijalon [France] ; Gaétan Burgio [Australie] ; Brendan J. Mcmorran [Australie] ; Simon J. Foote [Australie]Source :
- Blood [ 0006-4971 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Femelle, Ferrochelatase (antagonistes et inhibiteurs), Ferrochelatase (physiologie), Humains, Hème (métabolisme), Mâle, Paludisme à Plasmodium falciparum (), Paludisme à Plasmodium falciparum (enzymologie), Paludisme à Plasmodium falciparum (parasitologie), Phénotype, Plasmodium berghei (croissance et développement), Protoporphyrie érythropoïétique (), Protoporphyrie érythropoïétique (enzymologie), Protoporphyrie érythropoïétique (parasitologie), Protoporphyrines (pharmacologie), Souris, Souris de lignée C57BL, Érythrocytes (enzymologie), Érythrocytes (parasitologie).
- MESH :
- antagonistes et inhibiteurs : Ferrochelatase.
- croissance et développement : Plasmodium berghei.
- enzymologie : Paludisme à Plasmodium falciparum, Protoporphyrie érythropoïétique, Érythrocytes.
- métabolisme : Hème.
- parasitologie : Paludisme à Plasmodium falciparum, Protoporphyrie érythropoïétique, Érythrocytes.
- pharmacologie : Protoporphyrines.
- physiologie : Ferrochelatase.
- Animaux, Femelle, Humains, Mâle, Paludisme à Plasmodium falciparum, Phénotype, Protoporphyrie érythropoïétique, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Erythrocytes (enzymology), Erythrocytes (parasitology), Female, Ferrochelatase (antagonists & inhibitors), Ferrochelatase (physiology), Heme (metabolism), Humans, Malaria, Falciparum (enzymology), Malaria, Falciparum (parasitology), Malaria, Falciparum (prevention & control), Male, Mice, Mice, Inbred C57BL, Phenotype, Plasmodium berghei (growth & development), Protoporphyria, Erythropoietic (enzymology), Protoporphyria, Erythropoietic (parasitology), Protoporphyria, Erythropoietic (prevention & control), Protoporphyrins (pharmacology).
- MESH :
- chemical , antagonists & inhibitors : Ferrochelatase.
- enzymology : Erythrocytes, Malaria, Falciparum, Protoporphyria, Erythropoietic.
- growth & development : Plasmodium berghei.
- chemical , metabolism : Heme.
- parasitology : Erythrocytes, Malaria, Falciparum, Protoporphyria, Erythropoietic.
- chemical , pharmacology : Protoporphyrins.
- chemical , physiology : Ferrochelatase.
- prevention & control : Malaria, Falciparum, Protoporphyria, Erythropoietic.
- Animals, Female, Humans, Male, Mice, Mice, Inbred C57BL, Phenotype.
Abstract
Malarial parasite growth is impeded in erythropoietic protoporphyric erythrocytes because of decreased host cell ferrochelatase activity. A ferrochelatase competitive inhibitor prevents the growth of malarial parasites in normal red cells.
Url:
DOI: 10.1182/blood-2014-04-567149
PubMed: 25414439
PubMed Central: 4296013
Affiliations:
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Le document en format XML
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Smith</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Menzies Research Institute Tasmania</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">School of Medicine, University of Tasmania, Hobart, TAS, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Tasmania, Hobart, TAS</wicri:regionArea><wicri:noRegion>TAS</wicri:noRegion></affiliation></author><author><name sortKey="Jerkovic, Ante" sort="Jerkovic, Ante" uniqKey="Jerkovic A" first="Ante" last="Jerkovic">Ante Jerkovic</name><affiliation wicri:level="1"><nlm:aff id="aff3">Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Puy, Herve" sort="Puy, Herve" uniqKey="Puy H" first="Hervé" last="Puy">Hervé Puy</name><affiliation wicri:level="1"><nlm:aff id="aff4">Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes</wicri:regionArea><wicri:noRegion>Colombes</wicri:noRegion><wicri:noRegion>Colombes</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5">Centre de Recherche sur l’Inflammation, INSERM U1149, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche sur l’Inflammation, INSERM U1149, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff6">Groupe d′Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe d′Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Winship, Ingrid" sort="Winship, Ingrid" uniqKey="Winship I" first="Ingrid" last="Winship">Ingrid Winship</name><affiliation wicri:level="4"><nlm:aff id="aff7">Department of Medicine, University of Melbourne, Melbourne, VIC, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Office of Research, Royal Melbourne Hospital, Parkville, VIC, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Office of Research, Royal Melbourne Hospital, Parkville, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Deybach, Jean Charles" sort="Deybach, Jean Charles" uniqKey="Deybach J" first="Jean-Charles" last="Deybach">Jean-Charles Deybach</name><affiliation wicri:level="1"><nlm:aff id="aff4">Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes</wicri:regionArea><wicri:noRegion>Colombes</wicri:noRegion><wicri:noRegion>Colombes</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5">Centre de Recherche sur l’Inflammation, INSERM U1149, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche sur l’Inflammation, INSERM U1149, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gouya, Laurent" sort="Gouya, Laurent" uniqKey="Gouya L" first="Laurent" last="Gouya">Laurent Gouya</name><affiliation wicri:level="3"><nlm:aff id="aff5">Centre de Recherche sur l’Inflammation, INSERM U1149, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche sur l’Inflammation, INSERM U1149, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff6">Groupe d′Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Groupe d′Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Van Dooren, Giel" sort="Van Dooren, Giel" uniqKey="Van Dooren G" first="Giel" last="Van Dooren">Giel Van Dooren</name><affiliation wicri:level="1"><nlm:aff id="aff9">Research School of Biology, Australian National University, Canberra, ACT, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Research School of Biology, Australian National University, Canberra, ACT</wicri:regionArea><wicri:noRegion>ACT</wicri:noRegion></affiliation></author><author><name sortKey="Goodman, Christopher Dean" sort="Goodman, Christopher Dean" uniqKey="Goodman C" first="Christopher Dean" last="Goodman">Christopher Dean Goodman</name><affiliation wicri:level="4"><nlm:aff id="aff10">School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sturm, Angelika" sort="Sturm, Angelika" uniqKey="Sturm A" first="Angelika" last="Sturm">Angelika Sturm</name><affiliation wicri:level="4"><nlm:aff id="aff10">School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Manceau, Hana" sort="Manceau, Hana" uniqKey="Manceau H" first="Hana" last="Manceau">Hana Manceau</name><affiliation wicri:level="1"><nlm:aff id="aff4">Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes</wicri:regionArea><wicri:noRegion>Colombes</wicri:noRegion><wicri:noRegion>Colombes</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5">Centre de Recherche sur l’Inflammation, INSERM U1149, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche sur l’Inflammation, INSERM U1149, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mcfadden, Geoffrey Ian" sort="Mcfadden, Geoffrey Ian" uniqKey="Mcfadden G" first="Geoffrey Ian" last="Mcfadden">Geoffrey Ian Mcfadden</name><affiliation wicri:level="4"><nlm:aff id="aff10">School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="David, Peter" sort="David, Peter" uniqKey="David P" first="Peter" last="David">Peter David</name><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff11">Institut Pasteur, Unité d’Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité d’Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff11">Institut Pasteur, Unité d’Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité d’Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Burgio, Gaetan" sort="Burgio, Gaetan" uniqKey="Burgio G" first="Gaétan" last="Burgio">Gaétan Burgio</name><affiliation wicri:level="1"><nlm:aff id="aff3">Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Mcmorran, Brendan J" sort="Mcmorran, Brendan J" uniqKey="Mcmorran B" first="Brendan J." last="Mcmorran">Brendan J. Mcmorran</name><affiliation wicri:level="1"><nlm:aff id="aff3">Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Foote, Simon J" sort="Foote, Simon J" uniqKey="Foote S" first="Simon J." last="Foote">Simon J. Foote</name><affiliation wicri:level="1"><nlm:aff id="aff3">Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12">The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The John Curtin School of Medical Research, Australian National University, Canberra, ACT</wicri:regionArea><wicri:noRegion>ACT</wicri:noRegion></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Erythrocytes (enzymology)</term><term>Erythrocytes (parasitology)</term><term>Female</term><term>Ferrochelatase (antagonists & inhibitors)</term><term>Ferrochelatase (physiology)</term><term>Heme (metabolism)</term><term>Humans</term><term>Malaria, Falciparum (enzymology)</term><term>Malaria, Falciparum (parasitology)</term><term>Malaria, Falciparum (prevention & control)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Phenotype</term><term>Plasmodium berghei (growth & development)</term><term>Protoporphyria, Erythropoietic (enzymology)</term><term>Protoporphyria, Erythropoietic (parasitology)</term><term>Protoporphyria, Erythropoietic (prevention & control)</term><term>Protoporphyrins (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Ferrochelatase (antagonistes et inhibiteurs)</term><term>Ferrochelatase (physiologie)</term><term>Humains</term><term>Hème (métabolisme)</term><term>Mâle</term><term>Paludisme à Plasmodium falciparum ()</term><term>Paludisme à Plasmodium falciparum (enzymologie)</term><term>Paludisme à Plasmodium falciparum (parasitologie)</term><term>Phénotype</term><term>Plasmodium berghei (croissance et développement)</term><term>Protoporphyrie érythropoïétique ()</term><term>Protoporphyrie érythropoïétique (enzymologie)</term><term>Protoporphyrie érythropoïétique (parasitologie)</term><term>Protoporphyrines (pharmacologie)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Érythrocytes (enzymologie)</term><term>Érythrocytes (parasitologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Ferrochelatase</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Ferrochelatase</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Plasmodium berghei</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term><term>Protoporphyrie érythropoïétique</term><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Erythrocytes</term><term>Malaria, Falciparum</term><term>Protoporphyria, Erythropoietic</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Plasmodium berghei</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Heme</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Hème</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term><term>Protoporphyrie érythropoïétique</term><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Erythrocytes</term><term>Malaria, Falciparum</term><term>Protoporphyria, Erythropoietic</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Protoporphyrines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Protoporphyrins</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Ferrochelatase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Ferrochelatase</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Malaria, Falciparum</term><term>Protoporphyria, Erythropoietic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Phenotype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Paludisme à Plasmodium falciparum</term><term>Phénotype</term><term>Protoporphyrie érythropoïétique</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Malarial parasite growth is impeded in erythropoietic protoporphyric erythrocytes because of decreased host cell ferrochelatase activity.</p></list-item><list-item><p>A ferrochelatase competitive inhibitor prevents the growth of malarial parasites in normal red cells.</p></list-item></list></p></div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Paris</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Smith, Clare M" sort="Smith, Clare M" uniqKey="Smith C" first="Clare M." last="Smith">Clare M. Smith</name></noRegion><name sortKey="Burgio, Gaetan" sort="Burgio, Gaetan" uniqKey="Burgio G" first="Gaétan" last="Burgio">Gaétan Burgio</name><name sortKey="Foote, Simon J" sort="Foote, Simon J" uniqKey="Foote S" first="Simon J." last="Foote">Simon J. Foote</name><name sortKey="Foote, Simon J" sort="Foote, Simon J" uniqKey="Foote S" first="Simon J." last="Foote">Simon J. Foote</name><name sortKey="Goodman, Christopher Dean" sort="Goodman, Christopher Dean" uniqKey="Goodman C" first="Christopher Dean" last="Goodman">Christopher Dean Goodman</name><name sortKey="Jerkovic, Ante" sort="Jerkovic, Ante" uniqKey="Jerkovic A" first="Ante" last="Jerkovic">Ante Jerkovic</name><name sortKey="Mcfadden, Geoffrey Ian" sort="Mcfadden, Geoffrey Ian" uniqKey="Mcfadden G" first="Geoffrey Ian" last="Mcfadden">Geoffrey Ian Mcfadden</name><name sortKey="Mcmorran, Brendan J" sort="Mcmorran, Brendan J" uniqKey="Mcmorran B" first="Brendan J." last="Mcmorran">Brendan J. Mcmorran</name><name sortKey="Sturm, Angelika" sort="Sturm, Angelika" uniqKey="Sturm A" first="Angelika" last="Sturm">Angelika Sturm</name><name sortKey="Van Dooren, Giel" sort="Van Dooren, Giel" uniqKey="Van Dooren G" first="Giel" last="Van Dooren">Giel Van Dooren</name><name sortKey="Winship, Ingrid" sort="Winship, Ingrid" uniqKey="Winship I" first="Ingrid" last="Winship">Ingrid Winship</name><name sortKey="Winship, Ingrid" sort="Winship, Ingrid" uniqKey="Winship I" first="Ingrid" last="Winship">Ingrid Winship</name></country><country name="France"><noRegion><name sortKey="Puy, Herve" sort="Puy, Herve" uniqKey="Puy H" first="Hervé" last="Puy">Hervé Puy</name></noRegion><name sortKey="David, Peter" sort="David, Peter" uniqKey="David P" first="Peter" last="David">Peter David</name><name sortKey="Deybach, Jean Charles" sort="Deybach, Jean Charles" uniqKey="Deybach J" first="Jean-Charles" last="Deybach">Jean-Charles Deybach</name><name sortKey="Deybach, Jean Charles" sort="Deybach, Jean Charles" uniqKey="Deybach J" first="Jean-Charles" last="Deybach">Jean-Charles Deybach</name><name sortKey="Gouya, Laurent" sort="Gouya, Laurent" uniqKey="Gouya L" first="Laurent" last="Gouya">Laurent Gouya</name><name sortKey="Gouya, Laurent" sort="Gouya, Laurent" uniqKey="Gouya L" first="Laurent" last="Gouya">Laurent Gouya</name><name sortKey="Manceau, Hana" sort="Manceau, Hana" uniqKey="Manceau H" first="Hana" last="Manceau">Hana Manceau</name><name sortKey="Manceau, Hana" sort="Manceau, Hana" uniqKey="Manceau H" first="Hana" last="Manceau">Hana Manceau</name><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name><name sortKey="Puy, Herve" sort="Puy, Herve" uniqKey="Puy H" first="Hervé" last="Puy">Hervé Puy</name><name sortKey="Puy, Herve" sort="Puy, Herve" uniqKey="Puy H" first="Hervé" last="Puy">Hervé Puy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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